A MODIFIED DELPHI APPROACH TO DEVELOP A TRIAL PROTOCOL FOR ANTIBIOTIC DE-ESCALATION IN PATIENTS WITH SUSPECTED SEPSIS

A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis

Abstract Background: Early administration of antibiotics in sepsis is associated with improved patient outcomes, but safe and generalizable approaches to de-escalate or discontinue antibiotics after suspected sepsis events are unknown.Methods: We used a modified Delphi approach to identify safety criteria for an opt-out protocol to guide de-escalat

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Severe isoniazid related sideroblastic anemia

Isoniazid induced sideroblastic anemia is a rare event.We report case of a iphone 14 price chicago 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment.While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, nightstick twm-850xl reticulocytes were very lo

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Computational quantification and characterization of independently evolving cellular subpopulations within tumors is critical to inhibit anti-cancer therapy resistance

Abstract Background Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies.Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer.For optimal

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Melting and draining tests on glass waste form for the immobilization of Cs, Sr, and rare-earth nuclides using a cold-crucible induction melting system

Cold-crucible induction melting (CCIM) technology has been intensively studied as an advanced vitrification process for the immobilization of highly radioactive waste.This technology uses high-frequency induction to melt a glass matrix and waste, while canon imageclass mf227dw the outer surface of the crucible is water-cooled, resulting in the form

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